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KMID : 0613820160260101207
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Journal of Life Science
2016 Volume.26 No. 10 p.1207 ~ p.1213
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Single Dose Oral Toxicity Test of Ethanol Extracts of Schisandrae fructus and Mori folium, and their Mixture in ICR Mice
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Choi Eun-Ok
Kwon Da-Hye
Kim Min-Young
Hwang Young-Hoon
Kim Hong-Jae
Ahn Kyu-Im
Jeong Jin-Woo
Lee Ki-Won
Kim Ki-Young
Kim Sung-Gu
Choi Young-Whan
Hong Su-Hyun
Park Cheol
Choi Yung-Hyun
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Abstract
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Schisandrae fructus (SF) and Mori folium (MF) have been used as traditional medicines for thousands of years in parts of Asia, including Korea, China, and Japan. Recent researches on SF and MF have documented a wide spectrum of therapeutic properties, including anti-microbial, anti-inflammatory, anti-oxidative, immunomodulatory and anti-angiogenesis effects. However, the toxicity and safety of SF and MF, and their mixture (medicinal herber mixture, MHMIX) were not confirmed. Therefore, this study was performed to evaluate the acute toxicity and safety of SF, MF and MHMIX. SF, MF and MHMIX were orally administered at a dose of 5,000 mg/kg in ICR mice. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing, upon necropsy. We also measured parameters of organ weight, clinical chemistry, and hematology. No dead and no clinical signs were found during the experiment period after administration of a single oral dose of SF, MF and MHMIX. There were no adverse effects on clinical signs, body weight, or organ weight and no gross pathological findings in any treatment group. Therefore, LD50 value of SF, MF and MHMIX may be over 5,000 mg/kg and it may have no side toxic effect to ICR mice. The results on the single-dose toxicity of SF, MF and MHMIX indicate that it is not possible to reach oral dose levels related to death or dose levels with any harmful side effects.
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KEYWORD
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ICR mice, Mori folium, Schisandrae fructus, single dose oral toxicity, safety
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